Respiratory Effects in Toluene Diisocyanate Manufacture: A Multidisciplinary Approach
نویسندگان
چکیده
منابع مشابه
Respiratory effects in toluene diisocyanate manufacture: a multidisciplinary approach.
A new plant manufacturing toluene diisocyanate (TDI) has provided a unique opportunity to investigate the effects of TDI vapor inhalation on respiratory health in a group of exposed workers who have been studied prior to the start of plant operation. In order to establish dose-response relationships and determine host factors, complete biologic monitoring, including pulmonary function and immun...
متن کاملEpidemiology of toluene diisocyanate (TDI)-induced respiratory disease.
This paper describes our experience with the respiratory effects of TDI. Five respiratory reactions attributable to TDI are described with supporting evidence. The reactions are sensitization, irritation from overexposure, acute loss of ventilatory capacity, accelerated loss of pulmonary function and induction of a general asthmatic state. Evidence is presented that suggests a safe exposure level.
متن کاملRespiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice.
Occupational asthma is the principal cause of work-related respiratory disease in the industrial world. In the absence of satisfactory models for predicting the potential of low molecular weight chemicals to cause asthma, we verified that dermal sensitization prior to intranasal challenge influences the respiratory response using toluene diisocyanate (TDI), a known respiratory sensitizer. BALB/...
متن کاملNeurogenic Inflammation: Literature on Toluene Diisocyanate
William Meggs's recent article, "Neuro-genic Inflammation and Sensitivity to Environmental chemicals" (EHP 101:234-238), provides a useful introduction to a rapidly growing area of knowledge in physiology and posits a number of interesting hypotheses regarding the health effects of airborne chemicals. Some specific technical points, however, merit comment. Meggs describes the common chemical se...
متن کاملReference exposure levels for toluene diisocyanate
The Office of Environmental Health Hazard Assessment (OEHHA) is required to develop guidelines for conducting health risk assessments under the Air Toxics Hot Spots Program (Health and Safety Code Section 44360 (b) (2)). OEHHA developed a Technical Support Document (TSD) in response to this statutory requirement that describes acute, 8 hour and chronic RELs and was adopted in December 2008. The...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1975
ISSN: 0091-6765
DOI: 10.2307/3428331